Exploring the potential of spray-dried porcine plasma in canine health

Spray-dried porcine plasma (SDP) has long been used in both food and feed for its water-binding and immune supporting properties. Its immunological benefits have recently gained more attention in scientific literature.

In 2023, Wageningen University and Sonac, part of Darling Ingredients, launched a larger research project to investigate the use of SDP in dogs with both acute and chronic intestinal problems.

SDP is produced by spray drying the plasma component of porcine blood and contains various proteins, including immunoglobulins.

These immunoglobulins serve as key defense mechanisms in the body, with several varieties targeting a broad range of pathogens.

Previous studies have shown that SDP supports intestinal health, particularly during bacterial challenges or in cases of long-term intestinal diseases.

However, most existing research has focused on small animals or production animals like pigs and chickens. Data on SDP’s potential benefits for dogs remains limited.

Collaborative research project

The current project comprises several linked research questions. Initial efforts have focused on the ability of porcine immunoglobulins to bind bacterial and viral pathogens associated with canine intestinal issues.

Results are expected to be published soon.

Researchers are also examining whether the presence of porcine immunoglobulins can enhance the function of immune cells by binding to pathogens.

While interaction between porcine immunoglobulins and canine immune cells has been observed, further in vitro testing is ongoing to determine whether this stimulates or suppresses the immune response.

Optimizing dietary integration of SDP

Another objective is to explore how SDP can be effectively incorporated into canine diets. Researchers are seeking to strike a balance between the heat and pressure used during processing and the functional concentration of SDP in the intestines to ensure optimal impact on canine digestion.

To validate earlier findings, in vivo trials have also been initiated. A completed safety study found that even high concentrations of SDP caused no health issues in healthy beagles. New studies involving privately owned dogs are now being set up.

These trials will focus on animals suffering from chronic diarrhea to assess whether immunoglobulins can provide measurable intestinal support.

Next steps in research

Early outcomes suggest that SDP may offer dietary benefits for dogs. The research team is now preparing to test how these results hold up in dogs with existing intestinal problems. Recruitment for the next phase of studies is expected to begin soon.