Could blood proteins boost a dog’s gut health?

Gastroenteritis, an inflammation of the stomach and intestines, is a common condition in dogs. It is often triggered by an imbalance in the gut microbiome, viral infections like canine parvovirus (CPV) or food allergens.

When these factors come into play, the immune system is activated, producing inflammatory cytokines. This inflammation damages local tissue and weakens the protective mucus layer in the intestines.

The potential role of plasma

Current treatments focus on dietary changes, antibiotics and immunosuppressants. However, emerging research points to an additional avenue of support: blood plasma.

Plasma proteins can support gut health through 2 main mechanisms. First, the Fab arms of immunoglobulins bind to pathogens, potentially reducing infections and inflammation by preventing harmful interactions between pathogens and the gut lining.

Second, the Fc tail of the immunoglobulin may engage with the local immune system, dampening the inflammatory response. This reduction in inflammation can help protect the gut lining, allowing it to heal and restoring its ability to absorb nutrients effectively.

Blood plasma has shown promising results in supporting intestinal health across various mammal species.

For example, studies on piglets and calves experiencing gastrointestinal problems have demonstrated that bovine and porcine plasma can provide protective effects similar to those of breast milk.

This has led Darling Ingredients to develop Proglobulin^®, aimed at achieving similar benefits for people’s canine companions.

What is Proglobulin?

Proglobulin is spray-dried blood plasma, used for bio-functional gut health. It consists primarily of proteins (approximately 80%), along with minerals and water.

The majority of the proteins are albumins and globulins, including antibodies that are crucial for maintaining a healthy immune system. Among these antibodies, immunoglobulin G (IgG) is the most abundant, but IgA and IgM are also present.

In addition to immunoglobulins, Proglobulin contains other bioactive components such as immune factors (transferrin, interleukins and cytokines) and cellular growth factors (IGF 1, IGF 2, EGF and TGF β).

These elements collectively contribute to its potential in supporting immune and intestinal health in dogs.

Research partnership

In a partnership between Darling Ingredients International/Sonac and Wageningen University, researchers are investigating the effects of porcine plasma proteins – and specifically Proglobulin – on the canine gut.

Drawing on data from studies in piglets, the research aims to explore how plasma proteins can help regulate the immune response in dogs with gastrointestinal problems.

It is hoped that the research findings will eventually lead to better intestinal health and overall well-being for dogs.