The effects of collagen hydrolysate in dogs with osteoarthritis

Collagen hydrolysates have gained attention as a potential nutritional supplement for joint health, particularly in the context of osteoarthritis (OA) in dogs.

Since 2021, a PhD study has been underway to investigate the effects of Sonac’s Hydro-P Premium (HPP) in dogs with OA. The aim is to determine if the benefits seen in humans could apply to canines as well.

Collagen’s role in joint health

Collagen, a key structural component of cartilage, is found in skin, bones and joints. When heated, it transforms into gelatin, a substance historically known for alleviating joint pain.

Collagen hydrolysates are produced by breaking down the collagen into smaller peptides, which are more easily absorbed into the bloodstream when included in pet food.

In animal studies, these peptides have been shown to accumulate in the skin, cartilage and bones. However, similar studies in humans and dogs are limited, and further research is needed to confirm the full scope of benefits for dogs.

Study design and methodology

To assess the bioavailability in dogs, beagles were fed varying dosages of HPP. This experiment was key in understanding how the body absorbs collagen and helped establish dosing guidelines for dogs.

The study is now advancing to explore biomolecular mechanisms, aiming to understand how collagen hydrolysates influence inflammation and cartilage regeneration at a molecular level.

Collagen hydrolysate helps dogs with OA

For real-world application, two kibble formulations were created: one with collagen hydrolysate and one without. Dogs with radiographically confirmed OA were monitored throughout the study, observing the progression of their symptoms.

At the end of the study, the research team will analyze whether collagen hydrolysate effectively reduces pain and slows joint deterioration in dogs.

If proven effective, collagen could become a valuable addition to current osteoarthritis treatments, helping dogs move more comfortably and enjoy a better quality of life.

Empowering pet food manufacturers

The research into collagen hydrolysate’s impact on canine joint health utilized Hydro-P Premium (HPP), a high-quality ingredient from Sonac, by Darling Ingredients.

The brand’s commitment to research and product development empowers pet food manufacturers to create innovative, effective products, helping pets live longer, healthier and more active lives.